amyloidogenic proteins, in their fibrillar states, may be detrimental via different mechanisms: perspective of po-tential curative/preventive strategies against neurodege-nerative disorders

IOL: 'Dyslexia may be different brain disorders'

Peritoneal Dialysis in Dengue Shock Syndrome May Be Detrimental

Dengue shock syndrome is the most severe form of Dengue that can be fatal. Nonresponders to standard therapy need intensive care. This paper outlines the clinical features, complications, and outcomes of Dengue Shock Syndrome not responding to standard therapies and needing supportive care in a tertiary referral intensive care unit of a developing country. Nearly one-third die within 3 days of ...

Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms.

Abnormal protein assembly causes multiple devastating disorders in the central nervous system (CNS), such as Alzheimer's, Parkinson's, Huntington's, and prion diseases. Due to the now extended human lifespan, these diseases have been increasing in prevalence, resulting in major public health problems and the associated financial difficulties worldwide. The wayward proteins that lead to disease ...

Amyloidogenic potential of alpha-chymotrypsin in different conformational states.

Amyloid fibril formation is widely believed to be a generic property of polypeptide chains. In the present study, alpha-chymotrypsin, a well-known serine protease has been driven toward these structures by the use of two different conditions involving (I) high temperature, pH 2.5, and (II) low concentration of trifluoroethanol (TFE), pH 2.5. A variety of experimental methods, including fluoresc...

Research on C Reactive Proteins in Different Patients and Different States

C, Reactive Protein (CRP) is a serum globulin (a or /3) which reacts with the somatic antigen C-poly­saccharide of the pneumococcus in the presence of cal­cium ions in vitro, It is not a true antibody and appears nonspecifically in a wide variety of inflammatory necrotic, and infective conditions (e.g .• rheumatic fever and myo­cardial infarction).  CRP appears very early in several diseases p...

Atomistic modeling of collagen proteins in their fibrillar environment.

Molecular dynamics simulations can aid studies of the structural and physicochemical properties of proteins, by predicting their dynamics, energetics, and interactions with their local environment at the atomistic level. We argue that nonstandard protocols are needed to realistically model collagen proteins, which in their biological state aggregate to form collagen fibrils, and so should not b...